Guides
Canfora
ER4, E-4 and similar codes don’t mean the same thing on every glucose meter: each manufacturer numbers its own errors. On many meters, a code in this range points to a problem with the blood sample or strip, such as too little blood, blood applied too late, or a used or damaged strip. Retest with a new strip and a full drop of blood, then check your meter’s manual or helpline for the exact meaning.

The short answer
Manufacturers group errors into a few families. The numbers differ, but the fixes are similar.
| Family | What the meter detected | What to do |
|---|---|---|
| Sample errors | Too little blood, blood applied too late, sample applied twice, or blood on the wrong part of the strip | New strip; bigger drop; touch the drop to the strip’s edge or tip as the manual shows; don’t add more blood to the same strip |
| Strip errors | Strip used, wet, damaged, expired, inserted wrongly or the wrong type for this meter | New strip from a vial that has been kept closed; check expiry and the “discard after opening” date |
| Strip removed early | Strip moved or pulled out during the countdown | Retest and keep the meter still |
| Temperature | Meter or strips outside operating range (often about 10–40 °C) | Leave both at room temperature for 20–30 minutes, then retest |
| Meter/electronic faults | Internal fault, low battery, damaged port | Change the battery; if the error persists, call the helpline (number on the back of the meter) |
| HI / LO | Glucose above or below the meter’s range (often >33.3 or <1.1 mmol/L; >600 or <20 mg/dL) | Retest immediately; act on it if confirmed (see below) |
HI or LO is not a fault code. If a retest confirms “LO”, treat for hypoglycaemia at once (15 g fast-acting glucose, recheck in 15 minutes). If it confirms “HI”, check ketones if you can and contact your diabetes team or emergency services, especially with vomiting, abdominal pain, fast breathing or drowsiness.
If the same error appears with two or three fresh strips, run a control-solution test. If that also fails, the meter or strip batch is likely faulty: contact the manufacturer, who usually replace meters free of charge.
Even without an error message, a reading can be wrong. Under the ISO 15197:2013 standard, a meter may read up to 15% above or below the lab value (above 5.6 mmol/L or 100 mg/dL) and still pass. Readings can also be affected by low red-cell counts (anaemia) or high counts, dehydration, very high vitamin C doses with some strips, and testing on alternate sites while glucose is changing. If a result doesn’t fit your symptoms, wash your hands and retest from a fingertip. More on testing accurately is in the diabetes care guide.
On Call models differ, so check the error table in your model’s manual or the ACON/On Call support site. In general, codes in this range are sample or strip problems; retest with a new strip and a larger drop.
On several brands, E04-type codes indicate a sample or strip problem (for example too little blood or a used strip). Because meanings vary, confirm with your meter’s manual.
No. Strips are single-use; once blood or moisture has touched one, use a new strip.
Yes. Strips and meters left in a cold car or near an air conditioner often give temperature errors. Let them warm to room temperature first.
Date, time and memory resets are covered in how to reset a glucose meter.
More on this topic: testing accurately and the main diabetes medicines are covered in Diabetes Care: Glucose Meters, Diabetes Medicines and GLP-1 Pens.
Medical disclaimer: this article is general information, not a diagnosis or a personal recommendation. Check with your doctor or pharmacist before starting, stopping or combining medicines. Read the full disclaimer.