Bicalutamide CAS 90357-06-5 Supplier: Reliable Sources for High-Quality Chemicals

Bicalutamide (CAS 90357-06-5) is a non-steroidal androgen receptor antagonist widely used in the treatment of prostate cancer. It works by inhibiting the action of androgens, which are hormones that promote the growth of cancer cells. This makes it a crucial component in cancer therapy, particularly for patients with advanced prostate cancer.

Given its significant role in medical treatments, sourcing bicalutamide from a reliable supplier is essential to ensure the quality and efficacy of the drug. Reliable suppliers provide certified reference materials and adhere to stringent quality control standards, which is vital for pharmaceutical applications.

Key Characteristics of Bicalutamide CAS 90357-06-5

Chemical Properties

• Molecular Formula: C${18}$H${14}$F${4}$N${2}$O$_{4}$S
• Molecular Weight: 430.37 g/mol
• Melting Point: 191-193°C
• Boiling Point: 650.3±55.0°C (predicted)
• Density: 1.52±0.1 g/cm³ (predicted)
• Solubility: Soluble in DMSO (>5 mg/mL), DMF, and ethanol.

Molecular Structure

Bicalutamide is a non-steroidal antiandrogen with the following structure:

• Core Structure: N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-propanamide.
• Key Functional Groups:
  • Trifluoromethyl group at the meta position.
  • Cyano group at the para position.
  • Sulfonyl group linked to a fluorophenyl ring.

Pharmacological Uses

• Primary Use: Treatment of advanced prostate cancer by inhibiting the action of dihydrotestosterone and testosterone at target sites through competitive binding to the androgen receptor.
• Mechanism of Action: Bicalutamide binds to the androgen receptor (K$i$ = 12.5 μM; IC${50}$ = 1.2 μM), preventing its activation and subsequent upregulation of androgen-responsive genes.
• Additional Uses: Investigated for efficacy in treating colorectal, breast, pancreas, and non-small cell lung cancers.

Importance for Suppliers

• Purity and Stability: High purity (≥98%) and stability (≥4 years) are crucial for ensuring consistent pharmacological efficacy and safety.
• Storage Conditions: Requires storage at -20°C to maintain stability and prevent degradation.
• Regulatory Compliance: Suppliers must adhere to stringent regulatory standards to ensure the compound’s safety and effectiveness for clinical use.

These characteristics are essential for suppliers to guarantee the quality and reliability of bicalutamide, which directly impacts its therapeutic effectiveness and patient safety.

Criteria for Selecting a Bicalutamide CAS 90357-06-5 Supplier

When choosing a supplier for bicalutamide (CAS 90357-06-5), consider these essential factors:

1. Quality Assurance: Ensure the supplier provides high-quality products with consistent purity and potency. Look for suppliers that offer detailed Certificates of Analysis (CoA) and adhere to Good Manufacturing Practices (GMP).

2. Certification: Verify that the supplier is certified under relevant standards such as ISO 17034 and ISO/IEC 17025. These certifications indicate that the supplier meets international standards for quality and reliability.

3. Regulatory Compliance: Confirm that the supplier complies with local and international regulations, including REACH (Registration, Evaluation, Authorisation, and Restriction of Chemicals) and other pharmaceutical guidelines. This ensures the product is legally compliant and safe for use.

4. Reputation and Reliability: Research the supplier’s reputation in the industry. Look for reviews, testimonials, and any history of regulatory issues. A reliable supplier will have a strong track record of delivering quality products on time.

5. Support and Documentation: Ensure the supplier provides comprehensive support and documentation, including safety data sheets (SDS) and technical support for any queries or issues that may arise.

By focusing on these factors, you can select a supplier that meets your quality and regulatory needs for bicalutamide.

Top Global Suppliers of Bicalutamide CAS 90357-06-5

Here are some leading suppliers of Bicalutamide (CAS 90357-06-5) worldwide:

1. Sigma-Aldrich:

   • Reputation: Highly reputable in the life sciences industry.
   • Product Quality: Known for high-quality pharmaceutical secondary standards and certified reference materials.
   • Customer Service: Offers extensive support and documentation.

2. LGC Standards:

   • Reputation: Trusted for over 25 years in providing high-quality reference standards.
   • Product Quality: ISO 17034 accredited, ensuring reliable and accurate standards.
   • Customer Service: Strong customer support with extensive documentation and regulatory compliance.

3. Parchem:

   • Reputation: Recognized global supplier of specialty chemicals.
   • Product Quality: Provides high-purity active pharmaceutical ingredients (APIs).
   • Customer Service: Offers comprehensive support and quick response times.

These suppliers are known for their commitment to quality and customer satisfaction, making them reliable sources for Bicalutamide.

Benefits of Partnering with a Reliable Bicalutamide CAS 90357-06-5 Supplier

Sourcing bicalutamide (CAS 90357-06-5) from a trusted supplier offers several key advantages:

1. Consistent Product Quality: Trusted suppliers ensure high purity and adherence to stringent quality standards, which is crucial for reliable research and pharmaceutical applications.
2. Timely Delivery: Reliable suppliers have efficient logistics and inventory management systems, ensuring that you receive your orders promptly, minimizing downtime in your operations.
3. Technical Support: Established suppliers provide comprehensive technical support, including detailed product information, usage guidelines, and troubleshooting assistance, enhancing your overall experience and success in using the product.

These benefits collectively contribute to smoother operations and more reliable outcomes in your work.

Selecting the Right Supplier for Bicalutamide (CAS 90357-06-5)

Selecting the right supplier for bicalutamide (CAS 90357-06-5) is crucial to ensure the quality, efficacy, and safety of this critical pharmaceutical compound. A reliable supplier must provide high-purity products with consistent potency, adhere to stringent regulatory standards, and offer comprehensive support and documentation.

Key Considerations for Supplier Selection

When choosing a supplier, consider factors such as:

• Quality assurance
• Certification
• Regulatory compliance
• Reputation
• Reliability

Researching leading suppliers like Sigma-Aldrich, LGC Standards, and Parchem can help you find a trusted partner that meets your needs.

The Benefits of Selecting the Right Supplier

By selecting the right supplier, you can ensure:

• Consistent product quality
• Timely delivery
• Technical support

Ultimately, this contributes to smoother operations and more reliable outcomes in your work.