So, does low dose naltrexone make you gain weight? It’s a medication that’s usually taken in small doses, much lower than what’s used to treat opioid addiction. Some people are using it to help with chronic pain, autoimmune issues, and even some types of fatigue.
As more people try it, there are worries about gaining weight. We need to talk about this because it matters if you’re thinking about taking LDN.
Scientific studies and anecdotal evidence on low dose naltrexone (LDN) and weight gain present a mixed picture. Some studies suggest that LDN may help with weight loss, particularly in individuals with conditions like schizophrenia who are prone to antipsychotic-associated weight gain. A pilot study found that patients taking naltrexone experienced significant weight loss compared to those on a placebo.
Another study protocol aimed to investigate the safety and efficacy of naltrexone for antipsychotic-induced weight gain, suggesting its potential to reduce food cravings and weight.
A systematic review indicated that naltrexone, especially when combined with bupropion, can be effective for weight loss in obese patients. Anecdotal evidence from sources like suggests that weight gain is not a common side effect of naltrexone. Instead, it is often associated with weight loss, particularly when used in combination with bupropion.
Potential mechanisms by which LDN might impact weight include its action on opioid receptors, which play a role in appetite regulation and the brain’s reward pathways.
Naltrexone may decrease food cravings and alter the gut microbiota, contributing to weight loss.
Overall, there is more evidence supporting weight loss rather than weight gain with LDN, but individual responses can vary. Further research is needed to fully understand its effects and mechanisms.
The question of whether low dose naltrexone (LDN) makes you gain weight is a valid concern, especially considering its potential benefits for chronic pain, autoimmune issues, and fatigue. However, the scientific evidence on this topic presents a mixed picture.
Some studies suggest that LDN may actually help with weight loss, particularly in individuals with conditions like schizophrenia who are prone to antipsychotic-associated weight gain. A pilot study found significant weight loss in patients taking naltrexone compared to those on a placebo, and another study protocol aimed to investigate its potential to reduce food cravings and weight.
A systematic review also indicated that naltrexone, especially when combined with bupropion, can be effective for weight loss in obese patients. Anecdotal evidence from various sources suggests that weight gain is not a common side effect of LDN, but rather weight loss, particularly when used in combination with other medications.
The potential mechanisms by which LDN might impact weight include its action on opioid receptors, which play a role in appetite regulation and the brain’s reward pathways. Naltrexone may decrease food cravings and alter the gut microbiota, contributing to weight loss.
While there is more evidence supporting weight loss rather than weight gain with LDN, individual responses can vary. Further research is needed to fully understand its effects and mechanisms.
Ultimately, whether or not LDN makes you gain weight depends on various factors, including your individual health status, dosage, and combination of medications. It’s essential to consult with healthcare professionals for personalized advice before starting LDN or any other medication. Understanding the potential side effects of medications is crucial in making informed decisions about our health, and it’s always better to err on the side of caution when it comes to our well-being.