Nitroglycerin ointment is a special cream that’s applied directly to the skin. It helps relax blood vessels and increase blood flow, which can help with conditions like angina, Raynaud’s phenomenon, and anal fissures.
Nitroglycerin: 2 grams (20 mg/g)
White petrolatum: 98 grams
Mortar and pestle
Analytical balance
Weighing boats or papers
Spatula
Ointment jars or tubes
Plastic film or parchment paper
Preparation and Sanitization: Ensure all equipment is clean and sterilized. Wash hands and put on protective gloves.
Weighing the Ingredients:
Using an analytical balance, weigh 2 grams of nitroglycerin. Be very precise due to the potent nature of nitroglycerin.
Weigh 98 grams of white petrolatum.
Mixing:
Place the nitroglycerin into the mortar.
Add a small amount of white petrolatum to the nitroglycerin in the mortar.
Using a pestle, triturate (grind) the nitroglycerin and petrolatum together until they are well mixed. This helps in evenly distributing the nitroglycerin.
Gradually add the remaining white petrolatum to the mixture in portions, thoroughly mixing each portion before adding the next. Continue until all of the white petrolatum has been incorporated.
Ensuring Homogeneity:
Scrape down the sides of the mortar with a spatula and ensure all ingredients are thoroughly mixed.
The ointment should be homogenous, with no visible lumps or undissolved particles.
Packaging:
Using a spatula, transfer the compounded ointment into ointment jars or tubes. Press the ointment down to remove any air pockets.
Seal the jars or tubes. If using ointment jars, place a piece of plastic film or parchment paper over the ointment before sealing to prevent it from sticking to the lid.
Labeling:
Label the containers clearly with the name of the compounded preparation (Nitroglycerin 0.2% Ointment), the date of compounding, the expiration date, and any relevant usage instructions.
Storage:
Store the compounded ointment in a cool, dry place away from direct sunlight and out of reach of children and pets.
Remember, this guide is intended for informational purposes.
Compounding nitroglycerin ointment requires precision and care. Ensure you have the proper training and understanding of handling pharmaceutical substances before attempting.
The nitroglycerin 0.2% ointment compounding formula is crucial for creating a specialized cream that helps relax blood vessels and increase blood flow, which can alleviate conditions such as angina, Raynaud’s phenomenon, and anal fissures. This formula combines the potent ingredient nitroglycerin with white petrolatum to create a homogenous mixture that can be applied directly to the skin.
It is crucial to note that compounding this formula requires expertise and attention to detail, and individuals should not attempt it without proper training and experience.