Compounded tirzepatide is a special version of the medication tirzepatide. It’s used to help people with Type 2 diabetes and aid in weight loss. Unlike the regular version, compounded tirzepatide can be made by pharmacies to fit each person’s needs.
This means they can adjust the dosage or mix it with other medications if needed.
Factors influencing the longevity of compounded tirzepatide include storage conditions, expiration dates, and stability. Proper refrigeration is essential for maintaining its efficacy. Compounded tirzepatide typically retains its effectiveness for up to 90 days when stored in the refrigerator at 36°F to 46°F (2°C to 8°C).
Consistent temperature stability is crucial, as frequent temperature fluctuations can degrade the medication. Storage container integrity also plays a significant role; it should be kept in its original, airtight container to prevent exposure to air or moisture.
Clinical studies have shown that tirzepatide is effective in managing type 2 diabetes and promoting weight loss. The SURPASS-1 through -5 trials demonstrated robust efficacy of tirzepatide in reducing HbA1c levels and body weight over 40 to 52 weeks.
A systematic review and meta-analysis confirmed its superior blood glucose control and weight loss performance without an increased risk of hypoglycemia. Another study compared tirzepatide with other medications and found it to be the most effective in reducing HbA1c and promoting weight loss.
Expert opinions emphasize the importance of proper storage to maintain tirzepatide’s stability. High-quality compounding practices and consistent refrigeration are essential for preserving its efficacy.
Additionally, a stability-indicating UPLC method has been developed to quantify tirzepatide in bulk drug and pharmaceutical formulations, ensuring accurate detection and analysis of the medication.
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1tirzepatidemedics.org2diabetesjournals.org3www.frontiersin.org4bmcendocrdisord.biomedcentral.com5www.ijpir.com
Compounded tirzepatide can be stored in the refrigerator at 36°F to 46°F (2°C to 8°C) for up to 90 days, maintaining its efficacy during this period.
Proper refrigeration is essential to prevent degradation of the medication due to temperature fluctuations. It’s crucial to store compounded tirzepatide in its original, airtight container to prevent exposure to air or moisture.
Proper handling and storage are vital to maintain the effectiveness of compounded tirzepatide over time. Failure to do so can lead to degradation of the medication, rendering it less effective or even ineffective.