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Can I Take Nurofen Plus with Amoxicillin: Potential Interactions and Guidelines

Can I Take Nurofen Plus with Amoxicillin? A Comprehensive Guide

Welcome to our discussion on the potential interactions between Nurofen Plus and Amoxicillin. Whether you’re managing pain or fighting a bacterial infection, understanding how these medications work together is crucial. Can I take Nurofen Plus with Amoxicillin safely?

Let’s delve into the mechanisms of action and possible interactions to provide you with valuable insights and guidance.

Mechanisms of Action for Nurofen Plus and Amoxicillin

Let’s explore the mechanisms of action for Nurofen Plus and Amoxicillin:

  • Nurofen Plus (Ibuprofen and Codeine):
    • Ibuprofen: Belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by reducing hormones that cause pain and swelling in the body, specifically by inhibiting the enzyme cyclooxygenase (COX).12
    • Codeine: An opioid analgesic that blocks pain signals in the central nervous system, helping to alleviate pain and reduce stress. It is converted into morphine in the body.3
  • Amoxicillin:
    • Amoxicillin: An antibiotic that inhibits the synthesis of bacterial cell walls by interfering with peptidoglycan formation.

      This weakens the bacterial cell wall, leading to cell lysis and bacterial death.

Consult your healthcare provider for personalized advice on these medications. 🌟

A range of Nurofen products including tablets, capsules, and medicated plasters.

IMG Source: chemist-4-u.com


Amoxicillin Interactions and Disease Interactions

    Amoxicillin, a commonly prescribed antibiotic, interacts with several other drugs and supplements. Let’s explore these interactions:

  • Aspirin Low Strength: Amoxicillin may interact with aspirin, which is used for pain relief and reducing inflammation. It’s essential to monitor any adverse effects when taking these together.
  • Augmentin (amoxicillin / clavulanate): Since Augmentin contains amoxicillin, it’s crucial to be aware of potential interactions when using both medications.
  • Benadryl (diphenhydramine): Benadryl, an antihistamine, may interact with amoxicillin.

    Be cautious if you’re taking both.

  • Cymbalta (duloxetine): Cymbalta, an antidepressant, can interact with amoxicillin. Consult your healthcare provider if you’re using both.
  • Eliquis (apixaban): Eliquis, an anticoagulant, may have interactions with amoxicillin. Close monitoring is essential.
  • Fish Oil (omega-3 polyunsaturated fatty acids): Fish oil supplements and amoxicillin might interact.

    Discuss this with your doctor.

  • Flonase (fluticasone nasal): Flonase, a nasal spray, could interact with amoxicillin. Be cautious when using them concurrently.
  • Metoprolol Succinate ER (metoprolol): Metoprolol, a beta-blocker, may interact with amoxicillin. Consult your healthcare provider.
  • Norco (acetaminophen / hydrocodone): Norco, a pain medication, could interact with amoxicillin.

    Monitor for any adverse effects.

  • Tylenol (acetaminophen): Tylenol and amoxicillin may have interactions. Be vigilant when using both.
  • Vitamin B12 (cyanocobalamin): Vitamin B12 supplements and amoxicillin might interact. Discuss this with your doctor.
  • Vitamin C (ascorbic acid): Vitamin C and amoxicillin could have interactions.

    Consult your healthcare provider.

  • Vitamin D3 (cholecalciferol): Vitamin D3 supplements may interact with amoxicillin. Close monitoring is essential.
  • Xanax (alprazolam): Xanax, an anti-anxiety medication, may interact with amoxicillin. Be cautious if you’re taking both.
  • Zyrtec (cetirizine): Zyrtec, an antihistamine, could interact with amoxicillin.

    Monitor for any adverse effects.

Additionally, amoxicillin has disease interactions with:

  • Colitis
  • Mononucleosis
  • Diabetes
  • Phenylketonuria (PKU)
  • Renal dysfunction
  • Hemodialysis

Remember that individual responses to drug interactions can vary, so always consult your healthcare provider before starting or stopping any medication. If you have specific concerns about taking amoxicillin alongside any other medication, seek professional advice. 🌟

A box of Nurofen Plus tablets, a medication used to relieve pain.

IMG Source: irishexaminer.com


Interactions and Warnings

  • Amoxicillin:
    • Purpose: Amoxicillin is an antibiotic used to treat bacterial infections.
    • Interactions:
      • Painkillers: It’s generally safe to take over-the-counter painkillers like paracetamol, ibuprofen, or aspirin while on amoxicillin, as long as they are appropriate for you.
      • Contraceptives: Amoxicillin doesn’t affect hormonal contraceptives (such as birth control pills). However, if you experience vomiting or diarrhea while taking amoxicillin, it could potentially make your pill less effective at preventing pregnancy.
      • Anticoagulants (Warfarin): Amoxicillin may rarely alter the anti-blood-clotting effects of warfarin. Your doctor may want to monitor your blood clotting time if you’re taking both medicines.
      • Methotrexate: Amoxicillin may decrease the removal of methotrexate from the body, potentially increasing the risk of side effects.
      • Vaccines: The oral typhoid vaccine (Vivotif) should not be taken until at least three days after finishing a course of amoxicillin, as the antibiotic could make the vaccine less effective1.
  • Nurofen Plus:
    • Purpose: Nurofen Plus provides temporary relief of acute moderate pain and inflammation in patients over the age of 12 years.
    • Ingredients: It contains codeine, which the body converts into active morphine by a special liver enzyme.
    • Warnings: Nurofen Plus poses risks of abuse, misuse, and addiction, which can lead to overdose and death.

      It can also cause life-threatening respiratory depression23.

Remember to follow your doctor’s guidance and report any new or increased side effects while taking these medications.

If you have any concerns, don’t hesitate to reach out to your healthcare provider. 🌟

Three circles are in a row on a pink background. The first circle contains a glass of red wine, the second circle contains two pills, and the third circle contains two pills.

IMG Source: ctfassets.net



In conclusion, when considering the question, ‘Can I take Nurofen Plus with Amoxicillin?’ it’s essential to prioritize your health and well-being. While there are no direct interactions reported between these two medications, it is always prudent to consult your healthcare provider before combining any drugs. Be proactive in discussing your concerns and medical history to ensure the safe and effective use of both Nurofen Plus and Amoxicillin.

Your healthcare team can offer personalized advice based on your unique circumstances. Remember, your health is paramount, so stay informed, communicate openly with your medical professionals, and prioritize your overall well-being. If you have any doubts or experience unexpected symptoms, don’t hesitate to seek guidance promptly.

Your health is worth it.

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